Are we alone in the universe? Let us explore this question together. We will begin with a survey of stars, galaxies, and the universe, and then discuss great outstanding questions: What are dark matter, dark energy, and black holes? How did the universe begin? How will it end? Then we use recent advances in the Fermi paradox, the Rare Earth Hypothesis, the doomsday calculation, the Drake equation, the Great Filter, and other theories to help explore the question of whether or not we are alone. We finish with a far-ranging discussion of the philosophical and religious implications of either answer to that burning question, and what the question means for our quest to find knowledge, meaning, and purpose in the cosmos. | Lecture + Q&A.